Wright v. Fred Hutchinson Cancer Research Center et al - Documentary Evidence

• 100,000 shares Genetic Systems Co. stock for Dr. E. Donnall Thomas, April 1983 (700K PDF)
• 250,000 shares of stock and position for Dr. John Hansen, April 1983 (852K PDF)
• 10,000 shares of stock and consulting agreement for Dr. Paul Martin, Jan. 1981 (524K PDF)
• Investment prospectus touts company ties with The Hutch, June 1981 (3.2MB PDF)
• First application of Protocol 126 to Human Subjects Review committee, Dec. 16, 1980 (580K PDF)
• Committee minutes and transcript, Protocol 126 rejected, Jan. 20, 1981 (1.8MB PDF)
• Drs. Polissar and Ensinck comments on Protocol 126, April 6, 1981 (2MB PDF)
• Genetic Systems paid cash and stock for Hutchinson antibody rights, March 31, 1982 (824K PDF)
• Dr. Robert Bruce comments on Protocol 126, April 13, 1983 (424K PDF)
• Fred Hutchinson Center Conflict-of-Interest Policy, June 9, 1983 (336K PDF)
• Dr. Henry Kaplan's first letter to Dr. Thomas questioning safety of antibodies and conflicts of interest, Sept. 28, 1983 (660K PDF)
• Dr. Thomas' reply denying conflicts and warning IRB not to impede research, Oct. 14, 1983 (2MB PDF)
• Dr. Kaplan's letter to Dr. Robert Day asking for independent scientific review, Nov. 30, 1983 (416K PDF)
• Dr. Day's reply refusing an independent review but removing healthiest patients, Feb. 23, 1984 (540K PDF)
• Dottie Thomas' letter to board argues there is no alternative treatment, May 1, 1981 (244K PDF)
• Dr. Kaplan's third letter "once again" objecting to risks and financial conflicts, Dec. 17, 1984 (900K PDF)
• Dr. Fred Appelbaum tells Dr. Kaplan to stop complaining about financial conflicts, Dec. 20, 1984 (968K PDF)
• Patient consent form in 1993 finally made the risks of relapse and graft failure clear (1.2MB PDF)
• Excertps from published reports on the deaths (1MB PDF)

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The Whistleblower

• Dr. John Pesando's complaint to the Office for Protection from Research Risks, May 14, 1993 (1.1MB PDF)
• Hutch Administrator Dr. Robert Day's response to the complaint, Oct. 18, 1993 (7MB PDF)
• E-mail showing federal officials deciding "nothing wrong" with undisclosed financial interests, Dec. 10, 1993 (56K PDF)
• Federal investigator Kamal Mittal's analysis, questions and recommended course of action, April, 1993 (2.2MB PDF)
• OPRR closes the case, Sept. 5, 1995 (1MB PDF)
• Dr. Pesando writes two top federal officials, Dec. 01, 1995 (548K PDF)
• National Cancer Institute aide responds to Pesando, Jan. 11, 1996 (136K PDF)
• Fax shows OPRR wrote that letter for NCI, December 6, 1995 (140K PDF)
• Dr. Pesando writes Dr. Harold Varmus again, Oct. 16, 1996 (264K PDF)
• Dr. Henry Kaplan's letter to state investigator, Sept. 6, 1996 (332K PDF)
• Dr. John Pesando's letter to state investigator, Sept. 30, 1996 (444K PDF)
• Dr. E. Donnall Thomas' letter to state investigator, his only public statement on Protocol 126, Sept. 19, 1996 (608K PDF)

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The Breast-Cancer Experiment

• Replica of doctors' notes showing that four women died from the experimental treatment (72K PDF)
• Kathyrn Hamilton's informed consent explains that 10 patients given PTX/Cipro suffered no organ damage. But she's not told that this wasn't a formal study and the results don't mean much, Jan. 6, 1993 (136K PDF)
• Two of four patients in a previous breast-cancer study were killed by the chemotherapy, according to the protocol, Jan. 5, 1993 (168K PDF)
• James Bianco was the second researcher listed on the breast-cancer protocol (1.5MB PDF)
• In trying to raise capital from investors, CTI touted amazing results for a drug combination that it had already concluded didn't work, June 15, 1993 (516K PDF)
• Cell Therapeutics notifed The Hutch that it was cutting off the supply of the intravenous form of PTX, Nov. 10, 1992 (52K PDF)
• The protocol explains that two of four patients in one study and three of six in another were killed by the high-dose chemotherapy that Kathryn Hamilton would take, Jan. 5, 1993 (152K PDF)
• Hamilton's informed consent includes the results of an outdated study, Jan. 6, 1993 (136K PDF)
• The protocol explains that Hamilton will get a dose of chemotherapy previously thought to be too toxic, Jan. 6, 1993 (144K PDF)
• Doctor explains that Hamilton is likely to suffer nausea from chemotherapy, Jan. 6, 1993 (164K PDF)
• The informed consent repeatedly promises PTX in IV form, even though The Hutch didn't have the drug, Jan. 6, 1993 (736K PDF)
• Nurses' notes from Hamilton's first days in the hospital showing she was anxious about throwing up, Jan. 6, 1993 (296K PDF)
• Protocol doesn't say what to do if a patient dies from treatment, Jan. 5, 1993 (428K PDF)

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